ea0044p10 | Adrenal and Steroids | SFEBES2016
Hardy Rowan
, Hussain Zahrah
, Filer Andrew
, Buckley Christopher
, Lavery Gareth
, Cooper Mark
, Raza Karim
Muscle wasting is a common feature of inflammatory myopathies. Glucocorticoids (GCs), whilst effective at suppressing inflammation and inflammatory muscle loss, also cause myopathy with prolonged administration. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a bidirectional GC activating enzyme, potently up-regulated by inflammation within mesenchymal derived tissues. We assessed the regulation of this enzyme with inflammation in muscle and examined its functi...